Melanie B. Thomas, MD, MS

Associate Center Director for Experimental Therapeutics, Gibbs Cancer Center & Research Institute Spartanburg Regional Healthcare System


Dr. Melanie Thomas is a medical oncologist and recognized worldwide leader in the field of liver cancer. She most recently held the Grace E. DeWolff Chair in Gastrointestinal Oncology at the Medical University of South Carolina and served as Associate Director of Clinical Investigations. As Associate Director, Dr. Thomas had primary responsibility to oversee all clinical research infrastructure at Hollings Cancer Center. She worked to increase patient participation in clinical trials, optimizing the HCC's clinical research capabilities and opportunities and expanding the HCC Clinical Trials Network. 

Dr. Thomas has served as Principal Investigator on twenty-nine separate clinical trials, primarily in gastrointestinal cancers as well as held previous appointments at MD Anderson Cancer Center. Her clinical research focus includes developing effective systemic therapies for patients with cancers of the liver, gallbladder and bile ducts (hepatobiliary tumors) using novel or “targeted” therapies. Her work has lead to multi-institutional randomized clinical trials of novel drugs in hepatocellular cancer, which are now available at MUSC-HCC.